The ultrasonic cell crusher uses the dispersion effect of ultrasonic waves in the liquid to cause the liquid to produce cavitation, thereby breaking the solid particles or cell tissues in the liquid.
Ultrasonic cell crusher is a kind of elastic mechanical wave in the material medium. It is a form of fluctuation, so it can be used to detect the physiological and pathological information of the human body, as well as diagnostic ultrasound. At the same time, it is a form of energy. When a certain dose of ultrasound is transmitted in the organism, the interaction between them can cause the function and structure of the organism to change, that is, the biological effect of ultrasound. The effects of ultrasonic cell crusher on cells mainly include thermal, cavitation and mechanical effects. The thermal effect is that when the ultrasound propagates in the medium, the frictional force hinders the molecular vibration caused by the ultrasound, which converts part of the energy into local hyperthermia (42-43℃), because the critical lethal temperature of normal tissue is 45.7℃, while that of tumor tissue Normal tissues are highly sensitive, so the metabolism of tumor cells is impaired at this temperature, and DNA, RNA, and protein synthesis are affected, thereby killing cancer cells while normal tissues are not affected.
Ultrasonic cell crusher should be the primary effect of ultrasound. The alternating compression and expansion of medium particles during the propagation of ultrasound constitutes a pressure change, causing cell structure damage. The strength of the killing effect is closely related to the frequency and intensity of ultrasound. The ultrasonic cell crusher uses the dispersion effect of ultrasonic waves in the liquid to cause the liquid to produce cavitation, thereby breaking the solid particles or cell tissues in the liquid. The ultrasonic cell crusher is composed of two parts: an ultrasonic generator and a transducer. The ultrasonic generator transforms the mains electricity into 18-21KHz alternating electric energy to supply the transducer. The barium zirconate titanate piezoelectric vibrator is the heart of the transducer. It stretches and elastically deforms with the alternating voltage at a frequency of 18-21KHz, and the transducer vibrates longitudinally. The vibration wave of the ultrasonic cell crusher produces a cavitation effect through the titanium alloy horn immersed in the biological solution, which excites the biological particles in the medium to vibrate violently.
The ultrasonic cell crusher is automatically frequency-tuned and vibrated without manual adjustment. It has a temperature protection probe, which can effectively prevent damage to the sample due to temperature rise during the crushing process. It can be driven by a "normally open/normally closed" switch according to the feedback signal of the temperature probe. The operation of the external temperature control unit. Ultrasonic cell crusher probes can be down-converted through MICROTIP below 1/2" to achieve the crushing of trace samples. Different styles of probes such as closed cup (CUP) and continuous flow (FILLCELL) are available for purchase, with 96-well enzyme label Plate crushing head and dual-needle probe (to ensure experimental parallelism) probes are available for purchase. The ultrasonic cell crusher tracks and displays the actual effective power output. There are nine program memory functions, which are convenient for users to program and call, and the "work/intermittent" ratio can be adjusted Time cycle pulse type work, the time range is from 0.5 seconds to 1 hour, which improves the crushing effect and effectively prevents temperature rise. There is a question menu to protect the micro probe, which can effectively prevent the machine from being damaged by misoperation.
The ultrasonic cell crusher can be used to crush animal and plant cells, bacteria, dental spores or tissues. Disperse rare earth and various inorganic mineral powders. It is an ideal device for accelerating the reaction speed of chemistry, biology and physics and accelerating the degassing of liquids. Ultrasonic cell crusher can prepare latex with a size of nearly one-hundredth of a micron; homogenize the "immiscible" mixture; polymerize some substances and precipitate others. In short, the ultrasonic cell crusher can achieve multiple functions of extraction, crushing, emulsification, homogenization, suspension, mutation, aerosol suspension, accelerated desolvation, crystallization, and preparation of various biological samples under an electron microscope.
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